Синдром обструктивного апноэ сна часто связан с наличием у пациентов метаболического синдрома и ожирения. Ученые из Испании провели проспективное рандомизированно
В качестве испытуемых были набраны пациенты с тяжелым синдромом апноэ и ожирением без сахарного диабета. Из 80 пациентов 42 получали СИПАП-терапию, 38 – не получали. Перед исследованием и после него оценивалось комплексное состояние этих пациентов.
Через 12 недель лечения потеря веса, степень физической активности, распространеннос
Источник: Sleep Journal, pii: sp-00651-14.
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A Randomized Controlled Trial of Continuous Positive Airway Pressure on Glucose Tolerance in Obese Patients with Obstructive Sleep Apnea.
Obstructive slee
Design: Prospective randomized controlled trial.
Settings: Sleep clinics of Hospital Universitary de Bellvitge and Hospital de la Santa Creu i Sant Pau, Barcelona Spain.
Patients: with severe OSA and morbid obesity without diabetes.
Interventions: Patients received conservative (CT) versus CPAP treatment for 12 w.
Measurements: MetS components, homeostasis model assessment of insulin resistance (HOMA-IR), and oral glucose tolerance were assessed at baseline and after treatment.
Results: A total of 80 patients completed the study (42 CPAP and 38 CT patients). After 12 w of CPAP treatment, weight loss was similar in both groups and physical activity, prevalence of MetS, and HOMA-IR did not change in either group. In the CPAP group impaired glucose tolerance (IGT) reversed in nine patients and IGT developed in none, whereas IGT reversed in five patients and IGT developed in five patients in the CT group (P = 0.039 in the Fisher test). Changes in 2-h plasma glucose after glucose load were greater in the CPAP group than in the CT group (CPAP: -0.5 ± 1.5 versus CT: 0.33 ± 1.9, P = 0.007).
Conclusions: The improvement of glucose tolerance in morbidly obese patients with severe OSA, without changes in HOMA-IR, supports an improvement in peripheral insulin resistance after CPAP treatment.